• 专利附录
  • 专利说明
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    • 专利摘要:
    Prepared polyvinyl alcohol for use as a transparent occlusive bandage characterized in that it is applied in liquid, gel or cream form and solidifies. Applied as an occlusion in the phenol facial peel, it can be an advantageous replacement for the solid, sticky adhesive masks of plaster, plastic or fabric, opaque, laborious to make and, at times, difficult to remove used until now. It is easily removed by washing and cleansing with physiological saline when dermal-epidermal liquefaction has taken place. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2667627A1
    申请号:ES201600965
    申请日:2016-11-11
    公开日:2018-05-11
    发明作者:Angel José RUIZ NORRO
    申请人:Angel José RUIZ NORRO；
    IPC主号:
    专利说明:

     DESCRIPTION Prepared with polyvinyl alcohol for use as a transparent occlusive bandage characterized in that it is applied in a liquid, gel or cream form, it solidifies and provides transparent facial occlusion in the chemical peel of phenal. 10 15 SECTOR OF THE TECHNIQUE The invention is part of the field of medicine, especially repair and cosmetic plastic surgery, medical-surgical dermatology and aesthetic medicine. BACKGROUND OF THE INVENTION At the end of the 19th century dermatology was a well established medical field. Among many other pathologies, it dealt with syphilis and 20 other venereal disorders including their skin repercussions and, in this sense, also scars and smallpox marks. Facial skin aging, wrinkles and skin blemishes at the aesthetic level were not a field of wide medical interest so neither the treatment, nor the prevention of the various lesions associated with cutaneous photo-aging (skin cancer, actinic keratosis) and others). However, in an effort to help clients with severe skin problems, dermatologists were already experimenting with skin peels using previously known agents and also new compounds that, by then, were developed in the petrochemical and coal mining industry. : salicylic acid, resorcinol, trichloroacetic acid and fenal, which was discovered by German chemist Ferdinand Runge from coal tar in 1834. In this area the Viennese dermatologistFerdinand von Hebra (1816-1880) was a reference and an innovator. These pioneers in dermatology did not use chemical peels to treat the signs of aging. This field was open to other people without medical training who operated in beauty salons, where facial peels developed in practice. Of them there is reference in the newspapers of the time, for example in a publication of the Chicago Tribune in 1893. Thanks to this, more than by the scientific literature, we have news of methods of effective rejuvenating scrubs and of secret formulas that 10 used successfully people without medical training. From those practices today documented and scientifically developed thanks to the works of Kotler, Rullan, Hetter, Bensimon and others, there is news not only in the United States, but also in the Paris of the 1930s. Some of the best known "Iay peelers ", (practitioners of peeling legos 15 in medicine), of that time that followed the" great depression "of 1929 were: Jean DeDesley, Antoinette LaGradeé, Verner Kelsen, Cora Galenti, Arthur Gradé and, later, Maryanne Coopersmith and Miriam Maschek , among others. Each of them had a secret and effective formula that the medical profession did not know. Dr. Litton 20 reached a deal with Coopersmith and received, upon payment, a written formula without knowing for sure if it was the one actually used. It was later published by him and today known as the "Litton formula." In the 1960s the medical profession, in the US, while being interested in very effective treatments whose formulas containing phenol did not know, put pressure on the authorities for those non-medical establishments to close. Dr. George Miller McKee (1878-1955) used phenol in his patients to treat severe acne marks for many years and published his work in the British Journal of Dermatology in 1925. His work was continued by Dr. 30 Karp , born in the Soviet Union and formed in Paris, who developed her work as a dermatologist and worked with McKee in New York. Perhaps one of the first doctors to know in depth the secret of"Lay pellers" was Dr. Adolph Brown. Born in Eastern Europe in 1905, he graduated in medicine from the Detroit College of Medicine in 1933 and made his residency as an otolaryngologist. He returned to Europe, to Paris, where he met who his wife would be: dermatologist Dr. Marthe. With her 5 he returned to the United States and practiced the medical profession as a plastic surgeon. He patented several formulas for peelings, some with phenol Among them, the one he came to know and used: that of La Gradeé's lay peeler. He never exercised his patent rights when Litton, who obtained his 10 formula from Lay peeler Coopersmith, and Baker published their respective formulas in 1962. The formula known today as the phenol peeling formula par excellence among medical professionals is also known as Baker's formula. Baker knew the work of lay peelers Coopersmith and Miriam Maschek and the works of Dr. Brown, published 15 a formula in the famous magazine Plastic Recontructive Surgery in 1962. The procedure, which has become classic and widely practiced, understands after proper preparation of the patient the application of the preparation of phenol on the skin for about an hour, the performance of an uncomfortable adhesive mask that is maintained between 24-48 20 hours at the discretion of the doctor and then removed, sometimes under anesthesia or sedation . A drying antiseptic powder is then used for 4 to 8 days, moisturizers and petrolatum ointments until the re-epithelialization period has elapsed. After this treatment there is a period of transient erythema and the skin is greatly rejuvenated, free of spots, wrinkles and lesions associated with sun damage, precancerous lesions, keratosis, actinic keratosis and others. When the occlusion is not performed, the result of the procedure is of inferior quality in terms of regularity and depth, as observed in practice and several authors have documented. 30 In the medical literature the realization of the mask is described and in commercial preparations or kits for the realization of phenol peeling (exoderm®, skintech eye & lids® ...) instructions are given and even thematerial to prepare the covering of tape or polyurethanes. Throughout the years of my clinical practice I have had the opportunity to perform enough peeling procedures to design and apply the occlusion device that I describe with advantage. It is much more comfortable to apply, 5 being liquid, it spreads easily before drying. Once dry it remains as a transparent transparent occlusive film through which the evolution of the peeling can be observed during the time it remains in place. Its decomposition as the skin is liquefied by the effect of phenol and occlusion helps determine the best time for its total withdrawal. When progressively decomposing, the areas in which the peel is already "mature" are released from occlusion, in this sense it also acts as a "modulator." 15 EXPLANATION OF THE INVENTION The described device of occlusion of the phenol-croton peel consists of a liquid-gel that can easily spread solidifying once placed, remaining transparent and allowing the observation of the evolution of the procedure, decomposing as the liquefaction Dermo-epidermal progresses, modulating the procedure and being able to withdraw easily. It replaces with advantage the masks of cloth, polyurethane or other adhesive plaster that have always been and are currently applied in the procedure of chemical dermabrasion 25 facial or peel of phenol-croton and that are more laborious preparation and placement, which being opaque not They allow monitoring the evolution of the procedure or decide, seeing it, the best time for its withdrawal, sometimes difficult even requiring anesthesia or sedation. 30PREFERRED EMBODIMENT OF THE INVENTION The described occlusive device can be made by dissolving polyvinyl alcohol in water for injection, bi-distilled water or preservative water at 60 ° C, at 50% VN, slightly changing the proportions according to the fluidity, duration and timing of Desired drying In case of using preservative water it can be packaged, stored for a long time and distributed without deterioration. The use is made at room temperature. Once extended on the skin to be occluded, in one or several layers, drying can be accelerated with a stream of warm air, such as a hair dryer, at a low temperature. In the water solvent can be diluted, in addition to the preservatives that want to be used, products that are suitable as anesthetic lidocaine, anti-inflammatory, antiseptic, or other, and can be released progressively. The use of polyvinyl alcohol in contact with skin and mucous membranes has been proven safe, having been used in feminine intimate hygiene and adult incontinence products, as a biodegradable plastic sheet, in eye drops, as an artificial tear for the 20 dry eye treatment and as a lubricating solution for rigid contact lenses. The described occlusion device may be marketed in the European Union as a Class I or Class 25 medical device. 
    权利要求:
    Claims (1)
    [1]
    CLAIMS 1. Polyvinyl alcohol preparation for use as a transparent occlusive bandage characterized in that it is applied in liquid, gel or cream form and solidifies. 2. Preparation according to claim 1, characterized by incorporating drugs that are released progressively. 3. Preparation according to claim 1 containing 50% polyvinyl alcohol 4. Occlusive bandage for use in chemical phenol facial peeling characterized in that it contains the preparation of claims 1, 2 or 3. 20
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    同族专利:
    公开号 | 公开日
    ES2667627B1|2019-04-29|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    FR2566270A1|1984-06-25|1985-12-27|Ausonia Farma Srl|Pharmaceutical dosage forms in gel form, for the topical application of active principles|
    US5013769A|1988-08-22|1991-05-07|Medipro Sciences Limited|Method of making a hydrogel-forming wound dressing or skin coating material|
    US5679371A|1994-12-08|1997-10-21|Kuraray Co., Ltd.|Wound dressing|
    US5880216A|1995-12-22|1999-03-09|Kuraray Co., Ltd.|Polyvinyl alcohol and gel containing the same|
    法律状态:
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    优先权:
    申请号 | 申请日 | 专利标题
    ES201600965A|ES2667627B1|2016-11-11|2016-11-11|Prepared polyvinyl alcohol for use as a transparent occlusive bandage, applied in liquid, gel or cream form, solidifies and provides transparent facial occlusion in the phenol chemical peel.|ES201600965A| ES2667627B1|2016-11-11|2016-11-11|Prepared polyvinyl alcohol for use as a transparent occlusive bandage, applied in liquid, gel or cream form, solidifies and provides transparent facial occlusion in the phenol chemical peel.|
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